NeuroQSP Working Group
We unite mechanistic modeling, pharmacology, and human neuroscience to improve decision-making across CNS drug discovery and development — from molecular target to clinical outcome.
Why we exist
Brain drug programs fail more often, and later, than in almost any other therapeutic area. The gap between a molecular mechanism and a clinical effect is wide — spanning exposure, target engagement, circuit dynamics, and profound patient heterogeneity.
NeuroQSP builds the shared language and practical workflows that connect these scales, so quantitative models can actually inform the decisions that matter: which dose, which biomarker, which patient, which trial.
What we do
We connect the modeling traditions that rarely talk to each other — and the data that should inform them.
PBPK, PKPD, and systems-biology models that quantify exposure, target engagement, and downstream pharmacology.
Biophysical circuits, electrophysiology, and network models that turn mechanism into measurable neural dynamics.
EEG/MEG, imaging, and behavior linked back to model parameters as translational, clinically anchored readouts.
Where it pays off
The point of building shared workflows is to make better calls, earlier. NeuroQSP methods support decisions that are otherwise made on intuition alone:
Scope
Methods that generalize, applied wherever they help.
A working community
Leaders across QSP and neuroscience share methods and case studies. Every talk is recorded and posted to our channel.
Reference workflows, reading, models, and tools — a growing toolkit for practitioners new and experienced.
Connect with modelers, pharmacologists, and neuroscientists across academia, industry, and regulators.
Membership is open and free. Join to receive seminar invitations, contribute to shared workflows, and connect with the community.